The human brain utilizes lactate via the tricarboxylic acid cycle: a C-labelled microdialysis and high-resolution nuclear magnetic resonance study
نویسندگان
چکیده
1 Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, 1403, 29th Street NW, Calgary, Alberta T2N 2T9, Canada 2 Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK 3 Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Box 65, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK 4 Department of Chemistry, University of Cambridge, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK 5 Division of Anaesthesia, Department of Medicine, University of Cambridge, Box 93, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
منابع مشابه
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.
Energy metabolism in the human brain is not fully understood. Classically, glucose is regarded as the major energy substrate. However, lactate (conventionally a product of anaerobic metabolism) has been proposed to act as an energy source, yet whether this occurs in man is not known. Here we show that the human brain can indeed utilize lactate as an energy source via the tricarboxylic acid cycl...
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